HCID 18447545, compound → HCID 22933584, compound

HRID 1269792Notes

Reaction equation

HRID 1269792 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([O:10][CH2:11][CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[ClH:25].O1CCOCC1>>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12]([CH2:11][O:10][C:6]2[CH:5]=[C:4]3[C:9](=[CH:8][CH:7]=2)[NH:1][N:2]=[CH:3]3)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 18447545HCID 18447545, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 22933584HCID 22933584, compoundYield 95%

Procedure

To tert-butyl 4-[(1H-indazol-5-yloxy)methyl]piperidine-1-carboxylate (81.2 mg, 0.245 mmol) was added 4N-hydrochloric acid-dioxane (1 ml). After 1 hour, the resulting mixture was concentrated under reduced pressure, and the resulting residue was dissolved in methanol (0.5 ml) and crystallized from diethyl ether (10 ml). The crystals were filtered and then dried under reduced pressure to obtain 5-(piperidin-4-ylmethoxy)-1H-indazole dihydrochloride (71 mg, 95%).

Workup

  1. concentrationthe resulting mixture was concentrated under reduced pressure
  2. dissolutionthe resulting residue was dissolved in methanol (0.5 ml)
  3. customcrystallized from diethyl ether (10 ml)
  4. filtrationThe crystals were filtered
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-2443e74fd05f4805a0a9241854f00644
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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