HCID 18447545, compound → HCID 22933584, compound

Participants

Reaction Steps

To tert-butyl 4-[(1H-indazol-5-yloxy)methyl]piperidine-1-carboxylate (81.2 mg, 0.245 mmol) was added 4N-hydrochloric acid-dioxane (1 ml). After 1 hour, the resulting mixture was concentrated under reduced pressure, and the resulting residue was dissolved in methanol (0.5 ml) and crystallized from diethyl ether (10 ml). The crystals were filtered and then dried under reduced pressure to obtain 5-(piperidin-4-ylmethoxy)-1H-indazole dihydrochloride (71 mg, 95%).

Provenance & Evidence