HCID 22933709, compound → HCID 22934031, compound

HRID 1269848Notes

Reaction equation

HRID 1269848 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=1[O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[CH:10]2)([O-])=O>C(OCC)(=O)C.CO>[NH:12]1[C:13]2[C:9](=[CH:8][C:7]([O:6][C:5]3[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=3[NH2:1])=[CH:15][CH:14]=2)[CH:10]=[N:11]1

Participants

4

Reactant 1

HCID 22933709HCID 22933709, compound

Product 1

HCID 22934031HCID 22934031, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Under a hydrogen atmosphere at atmospheric pressure, a solution of the 5-(2-nitrophenoxy)-1H-indazole (56.7 mg, 0.222 mmol) obtained in Example 352 in a mixture of ethyl acetate (3 ml) and methanol (3 ml) was stirred at room temperature for 1.5 hours. The solution was filtered and then the filtrate was concentrated to obtain 2-(1H-indazol-5-yloxy)aniline (34.5 mg, 69%).

Workup

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-28701d4eb92845cfaa78b5a95c06f775
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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