Hydrochloric Acid → HCID 22933646, compound

Participants

Reaction Steps

To a solution of the N-(2,2-dimethyl-1,3-dioxan-5-yl)-1H-indazol-5-amine (23 mg, 0.0930 mmol) obtained in Example 532 in tetrahydrofuran (1 ml) was added 1N-hydrochloric acid (1 ml), and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction was terminated by the use of a saturated aqueous sodium hydrogencarbonate solution, followed by extraction with ethyl acetate, whereby 2-(1H-indazol-5-ylamino)propane-1,3-diol (16 mg, 84%) was obtained.

Provenance & Evidence