Hydrochloric Acid → HCID 22933646, compound

HRID 1269896Notes

Reaction equation

HRID 1269896 reaction equation
CC1(C)[O:7][CH2:6][CH:5]([NH:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][N:13]=[CH:12]3)[CH2:4][O:3]1.Cl>O1CCCC1>[NH:14]1[C:15]2[C:11](=[CH:10][C:9]([NH:8][CH:5]([CH2:4][OH:3])[CH2:6][OH:7])=[CH:17][CH:16]=2)[CH:12]=[N:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22933642HCID 22933642, compound

Product 1

HCID 22933646HCID 22933646, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the N-(2,2-dimethyl-1,3-dioxan-5-yl)-1H-indazol-5-amine (23 mg, 0.0930 mmol) obtained in Example 532 in tetrahydrofuran (1 ml) was added 1N-hydrochloric acid (1 ml), and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction was terminated by the use of a saturated aqueous sodium hydrogencarbonate solution, followed by extraction with ethyl acetate, whereby 2-(1H-indazol-5-ylamino)propane-1,3-diol (16 mg, 84%) was obtained.

Workup

  1. customThe reaction was terminated by the use of a saturated aqueous sodium hydrogencarbonate solution
  2. extractionfollowed by extraction with ethyl acetate

Sources & evidence

ORD record
ord-f01c8f4891dc41c7834457889e43539c
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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