反应详情

To a solution of the N-(1-benzylpiperidin-3-yl)-1H-indazol-5-amine (463 mg, 1.51 mmol) obtained in Example 535 in ethanol (10 ml) were added 10% Pd—C (50 mg) and then ammonium formate (952 mg, 15.1 mmol), and the resulting mixture was heated under reflux for 2 hours. The solid was removed by filtration using Celite, and the solvent was distilled off under reduced pressure. Chloroform/aqueous ammonia was added to the residue, followed by extraction with chloroform, and the extract solution was washed with a saturated aqueous sodium chloride solution, dried over sodium sulfate, and then distilled under reduced pressure to remove the solvent, whereby N-piperidin-3-yl-1H-indazol-5-amine (241 mg, 74%) was obtained.

1. temperatureunder reflux for 2 hours
2. customThe solid was removed by filtration
3. distillationthe solvent was distilled off under reduced pressure
4. additionChloroform/aqueous ammonia was added to the residue
5. extractionfollowed by extraction with chloroform
6. washthe extract solution was washed with a saturated aqueous sodium chloride solution
7. dry with materialdried over sodium sulfate
8. distillationdistilled under reduced pressure
9. customto remove the solvent