Diethyl Ether → HCID 18447345, compound

HRID 1269902Notes

Reaction equation

HRID 1269902 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([NH:9][C:10]1[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=1)[NH:15][N:14]=[CH:13]3)[CH2:2]2.[ClH:19].C(OCC)C.C(OCC)C>CO>[ClH:19].[ClH:19].[N:1]12[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]1)[CH:3]([NH:9][C:10]1[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=1)[NH:15][N:14]=[CH:13]3)[CH2:2]2

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 10953452Ether hydrochlorideHCID 18447344HCID 18447344, compound

Product 1

HCID 18447345HCID 18447345, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the N-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indazol-5-amine (178 mg, 0.75 mmol) obtained in Example 536 in methanol (5 ml) was added 1N-hydrochloric acid/diethyl ether (3 ml), and the resulting mixture was stirred at room temperature for 1 hour. After diethyl ether (15 ml) was added thereto, the solid formed was collected by filtration, washed with diethyl ether and then dried to obtain N-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indazol-5-amine dihydrochloride (210 mg, 91%).

Workup

  1. customthe solid formed
  2. filtrationwas collected by filtration
  3. washwashed with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-fe2abc25bc444ccfa88180d6a2f8f28b
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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