Diethyl Ether → HCID 18447345, compound

Participants

Reaction Steps

To a solution of the N-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indazol-5-amine (178 mg, 0.75 mmol) obtained in Example 536 in methanol (5 ml) was added 1N-hydrochloric acid/diethyl ether (3 ml), and the resulting mixture was stirred at room temperature for 1 hour. After diethyl ether (15 ml) was added thereto, the solid formed was collected by filtration, washed with diethyl ether and then dried to obtain N-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indazol-5-amine dihydrochloride (210 mg, 91%).

Provenance & Evidence