反应详情

Acetonitrile (5 ml), potassium carbonate (3.1 mmol, 423 mg) and N-carboethoxyphthalimide (3.1 mmol, 670 mg) were added to a solution of cis-3-amino-4,4-dimethylcyclohexanol hydrochloride (500 mg, 2.8 mmol) in water (10 ml), and the resulting mixture was stirred as it was for 2 hours. The crystals precipitated were collected by filtration and then recrystallized from chloroform-diethyl ether to obtain cis-2-(5-hydroxy-2,2-dimethylcyclohexyl)-1H-isoindole-1,3(2H)-dione (400 mg, 53%, containing about 10% of trans isomer) as white powder.

1. customThe crystals precipitated
2. filtrationwere collected by filtration
3. customrecrystallized from chloroform-diethyl ether