Ether hydrochloride → HCID 18447068, compound

HRID 1269915Notes

Reaction equation

HRID 1269915 reaction equation
[ClH:1].C(OCC)C.[CH3:7][C:8]1[C:16]([O:17][CH:18]2[CH2:23][CH2:22][CH:21]([CH2:24][NH2:25])[CH2:20][CH2:19]2)=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2>CO>[ClH:1].[CH3:7][C:8]1[C:16]([O:17][CH:18]2[CH2:23][CH2:22][CH:21]([CH2:24][NH2:25])[CH2:20][CH2:19]2)=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 18447067HCID 18447067, compound

Product 1

HCID 18447068HCID 18447068, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 1N-hydrochloric acid-diethyl ether solution (0.70 ml, 0.70 mmol) was added to a solution of 1-{4-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}-methanamine (150 mg, 0.578 mmol) in methanol (2 ml) at room temperature and stirred at the same temperature for 30 minutes. The solvent was distilled off under reduced pressure, and the residue was solidified with isopropyl alcohol-diisopropyl ether, filtered and then dried to obtain 1-{4-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}-methanamine hydrochloride (148 mg, 87%).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-7de1eec37cd94ce6ba2065725158c921
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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