Ether hydrochloride → HCID 18447068, compound

Participants

Reaction Steps

A 1N-hydrochloric acid-diethyl ether solution (0.70 ml, 0.70 mmol) was added to a solution of 1-{4-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}-methanamine (150 mg, 0.578 mmol) in methanol (2 ml) at room temperature and stirred at the same temperature for 30 minutes. The solvent was distilled off under reduced pressure, and the residue was solidified with isopropyl alcohol-diisopropyl ether, filtered and then dried to obtain 1-{4-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}-methanamine hydrochloride (148 mg, 87%).

Provenance & Evidence