4-(ethylthio)-1H-indazol-5-ol → 2-(cis-3-{[4-(ethylthio)-1H-indazol-5-yl]oxy}cyclohexyl)-1H-isoindole-1,3(2H)-dione

HRID 1269929Notes

Reaction equation

HRID 1269929 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@H:4]([N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])[CH2:3]1.Cl.[CH2:20]([S:22][C:23]1[C:31](O[C@@H]2CC[C@H](N)CC2)=[CH:30][CH:29]=[C:28]2[C:24]=1[CH:25]=[N:26][NH:27]2)[CH3:21].C(SC1C(O)=CC=C2C=1C=NN2)C>>[CH2:20]([S:22][C:23]1[C:31]([O:1][C@@H:2]2[CH2:7][CH2:6][CH2:5][C@H:4]([N:8]3[C:9](=[O:18])[C:10]4[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=4)[C:16]3=[O:17])[CH2:3]2)=[CH:30][CH:29]=[C:28]2[C:24]=1[CH:25]=[N:26][NH:27]2)[CH3:21]

Participants

4

Reactant 3

HCID 229339034-(ethylthio)-1H-indazol-5-olHCID 60011725trans-2-(3-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dioneHCID 178477322HCID 178477322, compound

Product 1

HCID 694325282-(cis-3-{[4-(ethylthio)-1H-indazol-5-yl]oxy}cyclohexyl)-1H-isoindole-1,3(2H)-dione

Procedure

The title compound was synthesized by carrying out reaction according to the method described in Example 610, except for using the trans-2-(3-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione obtained in Example 385, (b) and the 4-(ethylthio)-1H-indazol-5-ol obtained in Example 628, as starting materials.

Workup

  1. customreaction

Sources & evidence

ORD record
ord-ed2a4448d7b843d78083e82e0058b660
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

Loading…