4-(ethylthio)-1H-indazol-5-ol → 2-(trans-3-{[4-(ethylthio)-1H-indazol-5-yl]oxy}cyclohexyl)-1H-isoindole-1,3(2H)-dione

HRID 1269931Notes

Reaction equation

HRID 1269931 reaction equation
[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][C@H:4]([N:8]2[C:16](=[O:17])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])[CH2:3]1.[CH2:19]([S:21][C:22]1[C:30](O)=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[N:25][NH:26]2)[CH3:20]>>[CH2:19]([S:21][C:22]1[C:30]([O:1][C@H:2]2[CH2:7][CH2:6][CH2:5][C@H:4]([N:8]3[C:9](=[O:18])[C:10]4[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=4)[C:16]3=[O:17])[CH2:3]2)=[CH:29][CH:28]=[C:27]2[C:23]=1[CH:24]=[N:25][NH:26]2)[CH3:20]

Participants

3

Reactant 2

HCID 229339034-(ethylthio)-1H-indazol-5-olHCID 69434411(1S,3R)-2-(3-hydroxy-cyclohexyl)-isoindole-1,3-dione2×

Product 1

HCID 694310702-(trans-3-{[4-(ethylthio)-1H-indazol-5-yl]oxy}cyclohexyl)-1H-isoindole-1,3(2H)-dione

Procedure

The title compound was synthesized by carrying out reaction according to the method described in Example 610, except for using the cis-2-(3-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione obtained in Example 326, (d) and the 4-(ethylthio)-1H-indazol-5-ol obtained in Example 628, as starting materials.

Workup

  1. customreaction

Sources & evidence

ORD record
ord-ae0e87f7510a4fdcb086d5d65e2053ff
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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