Ether hydrochloride → HCID 69434052, compound

HRID 1269946Notes

Reaction equation

HRID 1269946 reaction equation
[ClH:1].C(OCC)C.[CH3:7][C:8]1[C:16]([O:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C@H:19]2[CH2:24][NH2:25])=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2>CC(O)C>[ClH:1].[CH3:7][C:8]1[C:16]([O:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C@H:19]2[CH2:24][NH2:25])=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 69430761HCID 69430761, compound

Product 1

HCID 69434052HCID 69434052, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Under a nitrogen atmosphere, 1M-hydrochloric acid-diethyl ether (249 μl, 0.249 mmol) was added to a solution of {trans-2-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}methylamine (53.8 mg, 0.207 mmol) in 2-propanol (1 ml) at room temperature. After 1 hour, the reaction solution was concentrated under reduced pressure and the resulting residue was crystallized from 2-propanol/acetonitrile to obtain {trans-2-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}methylamine hydrochloride (49.4 mg, 81%).

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was crystallized from 2-propanol/acetonitrile

Sources & evidence

ORD record
ord-4f21876a8e304c98a197b154e4a23951
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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