Ether hydrochloride → HCID 69433128, compound

HRID 1269950Notes

Reaction equation

HRID 1269950 reaction equation
[ClH:1].C(OCC)C.[CH3:7][C:8]1[C:16]([O:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][C@H:20]([CH2:24][NH2:25])[CH2:19]2)=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2>CC(O)C>[ClH:1].[CH3:7][C:8]1[C:16]([O:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][C@H:20]([CH2:24][NH2:25])[CH2:19]2)=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 69432272HCID 69432272, compound

Product 1

HCID 69433128HCID 69433128, compoundYield 74.1%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Under a nitrogen atmosphere, 1M-hydrochloric acid-diethyl ether (119 μl, 0.119 mmol) was added to a solution of {cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}methylamine (25.8 mg, 0.0995 mmol) in 2-propanol (1 ml) at room temperature. After 1 hour, the reaction solution was concentrated under reduced pressure and the resulting residue was crystallized from 2-propanol/diethyl ether to obtain {cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}methylamine hydrochloride (21.8 mg, 74%).

Workup

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was crystallized from 2-propanol/diethyl ether

Sources & evidence

ORD record
ord-60656bed647343f0b6158640a62b1cd8
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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