反应详情

温度

50 °C

A mixture of the trans-4-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexylamine (98.1 mg, 0.40 mmol) obtained in Example 408, methyl methacrylate (43 mg, 0.50 mmol) and methanol (2.0 ml) was stirred at 50° C. for 6 hours. The solvent was distilled off and the residue oil was subjected to elution by a silica gel column chromatography (ethyl acetate→ethyl acetate/triethylamine=20:1) to obtain methyl 3-({trans-4-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}-amino}propanoate (121 mg, 91%).

1. distillationThe solvent was distilled off
2. washthe residue oil was subjected to elution by a silica gel column chromatography (ethyl acetate→ethyl acetate/triethylamine=20:1)