Triethyl phosphite → Diethyl [(4-iodophenyl)methyl]phosphonate

HRID 1270026Notes

Reaction equation

HRID 1270026 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Cl)=[CH:4][CH:3]=1.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31215Triethyl phosphiteHCID 8172111-(Chloromethyl)-4-iodobenzene

Product 1

HCID 15166405Diethyl [(4-iodophenyl)methyl]phosphonate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4-iodobenzyl chloride and triethyl phosphite were put in a three-necked flask equipped with a reflux condenser, to which toluene was added and heated with stirring for 8 hours under reflux. The mixture was purified by the common method, to obtain diethyl 4-iodobenzylphosphonate.

Workup

  1. additionwas added
  2. temperatureheated
  3. temperatureunder reflux
  4. customThe mixture was purified by the common method

Sources & evidence

ORD record
ord-ceaad972f5ef492dba3981f83809dabe
Source dataset
uspto-grants-2007_04
Patent number
US07201976B2

Reaction notes

Loading…