Triethyl phosphite → Diethyl 3-Bromobenzylphosphonate

HRID 1270027Notes

Reaction equation

HRID 1270027 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]Cl.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 31215Triethyl phosphiteHCID 5230591-Bromo-3-(chloromethyl)benzene

Product 1

HCID 10979718Diethyl 3-Bromobenzylphosphonate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-bromobenzyl chloride (shown by the formula (vi)) and triethyl phosphite were put in a three-necked flask equipped with a reflux condenser, to which toluene was added and heated with stirring for 8 hours under reflux. The mixture was purified by the common method, to obtain diethyl 3-bromobenzylphosphonate (shown by the formula (vii)).

Workup

  1. customwere put in a three-necked flask
  2. additionwas added
  3. temperatureheated
  4. temperatureunder reflux
  5. customThe mixture was purified by the common method

Sources & evidence

ORD record
ord-083365ed216c416d989de739b47ed3da
Source dataset
uspto-grants-2007_04
Patent number
US07201976B2

Reaction notes

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