Hydrochloric Acid → Methyl 6-aminohexanoate hydrochloride

HRID 1270046Notes

Reaction equation

HRID 1270046 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8].[ClH:11]>O1CCOCC1>[ClH:11].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH3:10])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1810164Methyl 6-aminohexanoate

Product 1

HCID 11499324Methyl 6-aminohexanoate hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The methyl 6-aminohexanoate was dissolved in 40 mL of dioxane, followed by addition of 7.1 mL of 4N-hydrochloride solution of dioxane. After the mixture was stirred at room temperature for 30 minutes, the solvent was distilled off, followed by addition of ether to the residue. The precipitated crystals were isolated by filtration and dried under reduced pressure to yield 3.3 g of the target compound.

Workup

  1. distillationthe solvent was distilled off
  2. additionfollowed by addition of ether to the residue
  3. customThe precipitated crystals were isolated by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-bf5d63434cea466ebc6e34773baa4bef
Source dataset
uspto-grants-2007_04
Patent number
US07202093B2

Reaction notes

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