Methanol → HCID 131726326, compound

HRID 1270047Notes

Reaction equation

HRID 1270047 reaction equation
O1CCCC1.CO.[C:8]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH2:21][CH2:22][CH2:23][C@H:24]1[C@@H:32]2[C@@H:27]([NH:28][C:29]([NH:31]2)=[O:30])[CH2:26][S:25]1)[C:18]([NH2:20])=[O:19])([O:10]C)=[O:9].[OH-].[Na+]>O>[C:8]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH2:21][CH2:22][CH2:23][C@H:24]1[C@@H:32]2[C@@H:27]([NH:28][C:29]([NH:31]2)=[O:30])[CH2:26][S:25]1)[C:18]([NH2:20])=[O:19])([OH:10])=[O:9]

Participants

6

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 131726327HCID 131726327, compound

Product 1

HCID 131726326HCID 131726326, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

To a mixture of 25 mL of tetrahydrofuran and 25 mL of methanol, was dissolved 5-carbomethoxypentyl-D-biotinamide (800 mg, 2.15 mmol) obtained in Production Example 5-2, followed by addition of a solution of sodium hydroxide (2.33 g, 58.3 mmol) in water (12.5 mL) dropwise at room temperature. After the addition was completed, the mixture was heated to 40° C. and reacted for 2 hours.

Workup

  1. customobtained in Production Example 5-2
  2. additionAfter the addition
  3. customreacted for 2 hours

Sources & evidence

ORD record
ord-da01c4879dfe40adab301de12af2e961
Source dataset
uspto-grants-2007_04
Patent number
US07202093B2

Reaction notes

Loading…