Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Putrescine | HCID 1045 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 7-Chloro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13385163 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18448973 | HCID 18448973 | — |
Reaction Steps
To a solution of 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (1.0 g) in 1-methyl-2-pyrrolidinone (10 mL) was added butylenediamine (1.7 g). The mixture was heated at 130° C. for 16 h. The reaction mixture was cooled and poured into DCM (20 mL). The precipitate obtained was dispersed in MeOH and filtered to give the title compound (450 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07202221B2 |
|---|
| Source dataset | uspto-grants-2007_04 |
|---|
| ORD ID | ord-2fc7f92e20434abc9688500c3e9a699a |
|---|
| Source note | uspto-grants-2007_04 |
|---|
