Putrescine → HCID 18448973, compound

HRID 1270072Notes

Reaction equation

HRID 1270072 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:15]([OH:17])=[O:16])=[CH:8][N:9]2[CH:12]2[CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[CH2:19]([NH2:24])[CH2:20][CH2:21][CH2:22]N.C(Cl)Cl.C[N:29]1CCCC1=O>CO>[NH2:29][CH:20]([CH2:21][CH3:22])[CH2:19][NH:24][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:15]([OH:17])=[O:16])=[CH:8][N:9]2[CH:12]2[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 1045PutrescineHCID 6344DichloromethaneHCID 13387N-methyl-2-pyrrolidoneHCID 133851637-Chloro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 18448973HCID 18448973, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
130 °C

Procedure

To a solution of 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (1.0 g) in 1-methyl-2-pyrrolidinone (10 mL) was added butylenediamine (1.7 g). The mixture was heated at 130° C. for 16 h. The reaction mixture was cooled and poured into DCM (20 mL). The precipitate obtained was dispersed in MeOH and filtered to give the title compound (450 mg).

Workup

  1. temperatureThe reaction mixture was cooled
  2. customThe precipitate obtained
  3. filtrationfiltered

Sources & evidence

ORD record
ord-2fc7f92e20434abc9688500c3e9a699a
Source dataset
uspto-grants-2007_04
Patent number
US07202221B2

Reaction notes

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