HCID 131726329, compound → HCID 478987, compound

HRID 1270074Notes

Reaction equation

HRID 1270074 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:29])[C:18]([C:26]([OH:28])=[O:27])=[CH:19][N:20]2[CH:23]2[CH2:25][CH2:24]2)=[CH:15][C:14]=1[F:30])=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:29])[C:18]([C:26]([OH:28])=[O:27])=[CH:19][N:20]2[CH:23]2[CH2:24][CH2:25]2)=[CH:15][C:14]=1[F:30]

Participants

3

Reactant 1

HCID 131726329HCID 131726329, compound

Product 1

HCID 478987HCID 478987, compoundYield 135.8%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of intermediate 12 (100 mg) in 10% TFA/DCM (1 mL) was stirred at room temperature for 2 h. The solvent was partially evaporated under reduced pressure. For five times the residual was diluted in DCM (2 mL) and concentrated under reduced pressure. Final solvent evaporation afforded the title compound (103.4 mg).

Workup

  1. customThe solvent was partially evaporated under reduced pressure
  2. additionFor five times the residual was diluted in DCM (2 mL)
  3. concentrationconcentrated under reduced pressure
  4. customFinal solvent evaporation

Sources & evidence

ORD record
ord-5a477c55854146a89fc224e87623dbd0
Source dataset
uspto-grants-2007_04
Patent number
US07202221B2

Reaction notes

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