反应详情

A solution of 2-amino-6-chloro-benzonitrile (30 g), 2,5-dimethoxytetrahydrofuran (30 g) and 4-chloropyridine hydrochloride (17 g) in dioxane was heated to 70° C. for 2.5 h. The solvent was evaporated in vacuo. Dichloromethane was then added to the residue and the spent 4-chloropyridine hydrochloride filtered off. The dichloromethane was evaporated in vacuo to give 1-(3′chloro-2′-cyanophenyl)pyrrole (35 g)

1. customThe solvent was evaporated in vacuo
2. additionDichloromethane was then added to the residue
3. filtrationthe spent 4-chloropyridine hydrochloride filtered off
4. customThe dichloromethane was evaporated in vacuo