反应详情

A mixture of 5.15 g of ethyl 2-(p-formylphenyl)propionate and 4.5 g of morpholinocyclopentene in 10 ml of benzene was heated under reflux for 10 hours. After cooling, a mixture of 5 ml of conc. hydrochloric acid and 5 ml of water was added to the reaction mixture under ice-cooling and the resulting mixture was stirred at room temperature overnight. After addition of 100 ml of benzene, an organic layer was separated, washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to leave an oily substance, which was then distilled under reduced pressure to give 5.3 g of the desired product having a boiling point of 160°-165° C./0.25 mmHg.

1. temperaturewas heated
2. temperatureunder reflux for 10 hours
3. temperatureAfter cooling
4. additionwas added to the reaction mixture under ice-
5. temperaturecooling
6. customan organic layer was separated
7. washwashed with water
8. dry with materialdried over anhydrous sodium sulfate
9. distillationThe solvent was distilled off
10. customto leave an oily substance, which
11. distillationwas then distilled under reduced pressure