反应详情

温度

100 °C

4-[4-(2-Fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl]-piperazine-1-carboxylic acid tert-butyl ester (470 mg, 0.93 mmol) was dissolved in 3 ml ethanol. To this solution was added 1 ml of 10% ethanolic hydrochloric acid solution. The mixture was heated at 100° C. (steam bath) for 15 minutes, and then cooled to room temperature at which time a white crystalline solid formed. The solid was collected by filtration and dried at 70° C. under vacuum to provide 160 mg of 4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-8-piperazin-1-yl-3,4-dihydro-2H-benzo[1,4]oxazine as a hydrochloride salt. MP: 222.9–227.1° C. MS: (M+H) 479.

1. temperaturecooled to room temperature at which time a white crystalline solid
2. customformed
3. filtrationThe solid was collected by filtration
4. customdried at 70° C. under vacuum