HCID 18449249, compound → HCID 18449206, compound

HRID 1270173Notes

Reaction equation

HRID 1270173 reaction equation
[CH:1]([NH:4][C:5]1[C:6]2[N:7]([C:22]([O:25]C)=[N:23][N:24]=2)[C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[CH:10][CH:9]=2)([CH3:3])[CH3:2]>CC(O)=O.Br>[CH:1]([NH:4][C:5]1[C:6]2[N:7]([C:22](=[O:25])[NH:23][N:24]=2)[C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([CH2:15][N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1)=[CH:10][CH:9]=2)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 18449249HCID 18449249, compound

Product 1

HCID 18449206HCID 18449206, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Conditions

Temperature
23 °C

Procedure

A solution of isopropyl-(1-methoxy-7-morpholin-4-ylmethyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)-amine (32 mg) in AcOH (0.5 mL) and 48% HBr (0.5 mL) was heated at 50° C. for 2.5 hrs. After cooling to 23° C., the solution was concentrated. The resulting residue was concentrated from toluene, and then triturated with MeOH/EtOAc. The resulting solid was isolated by filtration, and then concentrated from MeOH to afford a light yellow solid. MS (M+H)+=341.3.

Workup

  1. concentrationthe solution was concentrated
  2. concentrationThe resulting residue was concentrated from toluene
  3. customtriturated with MeOH/EtOAc
  4. customThe resulting solid was isolated by filtration
  5. concentrationconcentrated from MeOH
  6. customto afford a light yellow solid

Sources & evidence

ORD record
ord-5201cece30de47daa93faafd590f12d9
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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