Sodium Hydroxide → HCID 69511797, compound

HRID 1270178Notes

Reaction equation

HRID 1270178 reaction equation
[CH:1]1([C:7]2[CH:32]=[CH:31][C:10]([C:11]([N:13]3[C:19]4[CH:20]=[C:21]([C:24]([O:26]C)=[O:25])[CH:22]=[CH:23][C:18]=4[CH2:17][N:16]4[CH:28]=[CH:29][CH:30]=[C:15]4[CH2:14]3)=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+:34]>C(O)C>[Na+:34].[CH:1]1([C:7]2[CH:32]=[CH:31][C:10]([C:11]([N:13]3[C:19]4[CH:20]=[C:21]([C:24]([O-:26])=[O:25])[CH:22]=[CH:23][C:18]=4[CH2:17][N:16]4[CH:28]=[CH:29][CH:30]=[C:15]4[CH2:14]3)=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18449089HCID 18449089, compound

Product 1

HCID 69511797HCID 69511797, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of the methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-8-carboxylate of Example 1, Step C (0.200 g) in anhydrous ethanol (2 mL) was added 2.5 N sodium hydroxide (1 equiv.). The reaction mixture was stirred for three days at room temperature and the solvent removed in vacuo to provide the title compound as a pale-yellow hygroscopic solid after drying over phosphorus pentoxide at 60° C.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-0c52f97e056d4632bdb151be13a20853
Source dataset
uspto-grants-2007_04
Patent number
US07202239B2

Reaction notes

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