Sodium Hydroxide → HCID 69511797, compound

Participants

Reaction Steps

To a stirred solution of the methyl 10-(4-cyclohexylbenzoyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-8-carboxylate of Example 1, Step C (0.200 g) in anhydrous ethanol (2 mL) was added 2.5 N sodium hydroxide (1 equiv.). The reaction mixture was stirred for three days at room temperature and the solvent removed in vacuo to provide the title compound as a pale-yellow hygroscopic solid after drying over phosphorus pentoxide at 60° C.

Provenance & Evidence