Ammonium Hydroxide → HCID 10295231, compound

HRID 1270188Notes

Reaction equation

HRID 1270188 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19](=[O:32])[C:20]3[CH:25]=[CH:24][C:23]([CH:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:22][CH:21]=3)[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].[OH-].[NH4+:36]>C(O)C>[CH:26]1([C:23]2[CH:22]=[CH:21][C:20]([C:19]([N:10]3[C:11]4[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=4[CH2:13][N:14]4[C:5]([C:3]([NH2:36])=[O:4])=[CH:6][CH:7]=[C:8]4[CH2:9]3)=[O:32])=[CH:25][CH:24]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 18449079HCID 18449079, compound

Product 1

HCID 10295231HCID 10295231, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,2,2-Trichloro-1-[10-cyclohexyl-benzoyl)-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl]-1-ethanone of Example 7 (0.60 g) was added to a pressure flask containing concentrated ammonium hydroxide (25 mL) and absolute ethanol (25 mL). The mixture was heated in an oil bath held at 110° C. for four hours. On cooling the title compound crystallized out and was filtered off to provide colorless crystals (0.66 g), m.p. 122–123° C.

Workup

  1. temperatureThe mixture was heated in an oil bath

Sources & evidence

ORD record
ord-3aab46cc938c48498fe962d303103d46
Source dataset
uspto-grants-2007_04
Patent number
US07202239B2

Reaction notes

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