反应详情

温度

20 °C

2.53 g (1.54 ml, 16.51 mmol) of phosphoryl chloride are added dropwise under argon to a solution of 1.57 g (5.50 mmol) of 5,7-dimethyl-2-(4-nitrophenyl)imidazo-[5,1-f][1,2,4]triazin-4-(3H)one from example 8A in 10 ml of dry pyridine at 0° C., and the mixture is stirred for 30 min at 20° C. Subsequently, 3.42 g (49.53 mmol) of 1,2,4-triazole are added, and the mixture is stirred overnight at RT. The reaction mixture is concentrated, the residue is treated with aqueous sodium hydrogencarbonate solution, and the mixture is extracted using dichloromethane. The organic phase is dried (sodium sulfate) and the solvent is removed in vacuo. The residue is purified by flash chromatography (eluent: dichloromethane/methanol 100:1).

1. stirringthe mixture is stirred overnight at RT
2. concentrationThe reaction mixture is concentrated
3. additionthe residue is treated with aqueous sodium hydrogencarbonate solution
4. extractionthe mixture is extracted
5. dry with materialThe organic phase is dried (sodium sulfate)
6. customthe solvent is removed in vacuo
7. customThe residue is purified by flash chromatography (eluent: dichloromethane/methanol 100:1)