Aluminium lithium hydride → HCID 10308515, compound

HRID 1270344Notes

Reaction equation

HRID 1270344 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O:9][C:10]([C:12]1[N:13]=[N:14][N:15]([C:17]2[CH:22]=[C:21]([F:23])[C:20]([N:24]3[CH2:29][CH2:28][S:27][CH2:26][CH2:25]3)=[C:19]([F:30])[CH:18]=2)[CH:16]=1)=O)C>C1COCC1>[F:23][C:21]1[CH:22]=[C:17]([N:15]2[CH:16]=[C:12]([CH2:10][OH:9])[N:13]=[N:14]2)[CH:18]=[C:19]([F:30])[C:20]=1[N:24]1[CH2:29][CH2:28][S:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 58842815HCID 58842815, compound

Product 1

HCID 10308515HCID 10308515, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of lithium aluminum hydride (161 mg, 4.24 mmol) in dry THF (10 mL) was added a solution of 1-(3,5-difluoro-4-thiomorpholin-4-yl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (1.0 g, 2.8 mmol), obtained in Preparation 22, in THF (10 mL) at 0° C. and stirred for 0.5 h. The reaction mixture was then quenched with saturated solution of sodium sulfate and filtered. The residue was washed with ethyl acetate and the combined filtrate was concentrated to yield the title alcohol (0.7 g, 88%).

Workup

  1. customThe reaction mixture was then quenched with saturated solution of sodium sulfate
  2. filtrationfiltered
  3. washThe residue was washed with ethyl acetate
  4. concentrationthe combined filtrate was concentrated

Sources & evidence

ORD record
ord-aa9143aa0cc247ea81d1670bc4c0a842
Source dataset
uspto-grants-2007_04
Patent number
US07202254B2

Reaction notes

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