Triethylamine → HCID 10126363, compound

HRID 1270345Notes

Reaction equation

HRID 1270345 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[F:6][C:7]1[CH:8]=[C:9]([N:20]2[CH:24]=[C:23]([CH2:25][OH:26])[N:22]=[N:21]2)[CH:10]=[C:11]([F:19])[C:12]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.CCN(CC)CC>C(Cl)Cl>[F:6][C:7]1[CH:8]=[C:9]([N:20]2[CH:24]=[C:23]([CH2:25][O:26][S:2]([CH3:1])(=[O:4])=[O:3])[N:22]=[N:21]2)[CH:10]=[C:11]([F:19])[C:12]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 10236452HCID 10236452, compound

Product 1

HCID 10126363HCID 10126363, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulfonyl chloride (0.1 mL, 2.23 mmol) was added dropwise to a solution of [1-(3,5-difluoro-4-morpholin-4-yl-phenyl)-1H-[1,2,3]triazol-4-yl]-methanol (0.6 g, 2.02 mmol), obtained in Example 1, and Et3N (0.6 mL, 4.4 mmol) in CH2Cl2 (30 mL) at 0° C. After stirring for 45 min the reaction mixture was washed successively with water, aqueous NaHCO3 and brine and dried over sodium sulfate. Evaporation of volatiles left the title compound as oily liquid (0.7 g, 93%).

Workup

  1. washwas washed successively with water, aqueous NaHCO3 and brine
  2. dry with materialdried over sodium sulfate
  3. customEvaporation of volatiles
  4. waitleft the title compound as oily liquid (0.7 g, 93%)

Sources & evidence

ORD record
ord-c3669f9cf9b04eacb3b21cbc5194fd0b
Source dataset
uspto-grants-2007_04
Patent number
US07202254B2

Reaction notes

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