HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → [3-(4-Methoxypyrimidin-2-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | tert-Butyl [3-(4-methoxypyrimidin-2-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetate | HCID 18449413 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | [3-(4-Methoxypyrimidin-2-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetic acid | HCID 18449378 | — |
Reaction Steps
tert-Butyl[3-(4-methoxypyrimidin-2-yl)-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetate from Step A (110 mg, 0.309 mmol) was dissolved in TFA (2 mL) and CH2Cl2 (2 mL) and the mixture was stirred at ambient temperature for 48 h, then concentrated in vacuo to give the title compound. MS: m/z=301 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07202251B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-6c95dc9911784779a345817d5d4650d3 |
| Source note | uspto-grants-2007_04 |