HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(6-Fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-(6-Fluoro-pyridin-2-yl)-2,4-dimethoxy-pyrimidine | HCID 58994216 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(6-Fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione hydrochloride | HCID 68690314 | 84% |
Reaction Steps
5-(6-Fluoro-pyridin-2-yl)-2,4-dimethoxy-pyrimidine (Prep74, 230 mg, 0.98 mmol) was dissolved in a solution of 4N HCl in dioxane (4 ml). After refluxing the reaction mixture for 1 hour, the solvent was removed under vacuum to give 200 mg of the title compound (84% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-52433a06d31e46f9a555363b4c4a650d |
| Source note | uspto-grants-2010_06 |