反应详情

To a solution of dry ortho-nitrophenol (79 mmol) in 200 ml of acetone there are added 127 mmol of potassium carbonate and also 79 mmol of diphenylmethane bromide. The reaction mixture is heated at reflux for 6 hours and, after the temperature has been lowered to ambient temperature, is stirred further overnight. The reaction mixture is filtered and rinsed with acetone. The filtrate is evaporated and then taken up in diethyl ether and hydrolysed. The aqueous phase is extracted with diethyl ether; the organic phase is then dried over magnesium sulphate, filtered and concentrated. The residue obtained is taken up in petroleum ether, filtered, rinsed with petroleum ether and then dried in vacuo, allowing the expected product to be isolated.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 6 hours
3. customhas been lowered to ambient temperature
4. filtrationThe reaction mixture is filtered
5. washrinsed with acetone
6. customThe filtrate is evaporated
7. extractionThe aqueous phase is extracted with diethyl ether
8. dry with materialthe organic phase is then dried over magnesium sulphate
9. filtrationfiltered
10. concentrationconcentrated
11. customThe residue obtained
12. filtrationfiltered
13. washrinsed with petroleum ether
14. customdried in vacuo
15. customto be isolated