Ethylamine → HCID 58842564, compound

HRID 1270441Notes

Reaction equation

HRID 1270441 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH:12][CH2:13][C:14]2([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:26]([NH2:28])[CH3:27]>O1CCCC1>[CH2:26]([NH:28][C:2]1[N:11]=[C:10]([NH:12][CH2:13][C:14]2([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[CH3:27]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 58842531HCID 58842531, compound

Product 1

HCID 58842564HCID 58842564, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

(2-chloro-quinazolin-4-yl)-(1-phenyl-cyclohexylmethyl)-amine (0.052 g; 0.15 mmol) was treated with 1 mL of a 2 M solution of ethylamine in tetrahydrofuran. The reaction vessel was tightly sealed and the reaction mixture was heated at 60° C. for 24 h. The volatile components were removed under vacuum and the crude residue was purified directly be preparative HPLC to give 0.020 g of N2-ethyl-N4-(1-phenyl-cyclohexylmethyl)-quinazoline-2,4-diamine as a white solid. LCMS m/z=361.2 (M+H)+

Workup

  1. customThe reaction vessel was tightly sealed
  2. customThe volatile components were removed under vacuum
  3. customthe crude residue was purified directly be preparative HPLC

Sources & evidence

ORD record
ord-136db72526ab471a901c7c8ad2c00093
Source dataset
uspto-grants-2007_04
Patent number
US07202253B2

Reaction notes

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