1-(3,3-Dimethoxy-propyl)-5-(6-fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione → HCID 58994196, compound

HRID 12706Notes

Reaction equation

HRID 12706 reaction equation
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[N:13]=2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]>C1COCC1>[F:18][C:14]1[N:13]=[C:12]([C:10]2[C:9](=[O:19])[NH:8][C:7](=[O:20])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=2)[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 1

HCID 589942011-(3,3-Dimethoxy-propyl)-5-(6-fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione

Product 1

HCID 58994196HCID 58994196, compoundYield 111.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(3,3-Dimethoxy-propyl)-5-(6-fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione (Prep76, 179 mg, 0.58 mmol) was dissolved in THF (4 ml) and 2N HClaq (0.5 ml) was added. The solution was then stirred at room temperature for 2 hours. THF was evaporated under vacuum and the aqueous residue was lyophilized to give 170 mg of a yellow powder that was used in the next step without further purification (quantitative yield).

Workup

  1. addition2N HClaq (0.5 ml) was added
  2. customTHF was evaporated under vacuum

Sources & evidence

ORD record
ord-f282dd20ba1842b0bc285859e2867010
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

Loading…