反应详情

To a stirred solution of propynyllithium at -25° is added a solution of 4-oxo-1-iodo-trans-1-octene in tetrahydrofuran. After the addition, the solution is stirred at -20° to -15° C. for 30 minutes. The reaction is quenched with a mixture of hexane and ice. The aqueous phase is separated and extracted with additional hexane. The combined hexane extracts are washed successively with water and brine. The solution is dried over magnesium sulfate and concentrated. The residue is subjected to column chromatography on silica gel with toluene to provide the product as an oil.

1. additionAfter the addition
2. customThe reaction is quenched with a mixture of hexane and ice
3. customThe aqueous phase is separated
4. extractionextracted with additional hexane
5. washThe combined hexane extracts are washed successively with water and brine
6. dry with materialThe solution is dried over magnesium sulfate
7. concentrationconcentrated