Hydrochloric Acid → (2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochloride

HRID 1270667Notes

Reaction equation

HRID 1270667 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])[CH2:6][CH2:5]1)(=O)C.[ClH:20]>>[ClH:20].[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)=[O:19]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Product 1

HCID 18759874(2,4-Difluorophenyl)(piperidin-4-yl)methanone hydrochlorideYield 85%

Procedure

56 g of 1-acetyl-4-(2,4-difluorobenzoyl)piperidine obtained in step A) was added to 190 ml of 6N hydrochloric acid, and then, the resulting mixture was refluxed for 5 hours. The reaction mixture was concentrated under a reduced pressure, 200 ml of 2-propanol was added to the residue, and then the mixture was stirred. The resulting solid was filtered and dried to obtain 46.6 g of the title compound (yield: 85%).

Workup

  1. temperaturethe resulting mixture was refluxed for 5 hours
  2. concentrationThe reaction mixture was concentrated under a reduced pressure, 200 ml of 2-propanol
  3. additionwas added to the residue
  4. filtrationThe resulting solid was filtered
  5. customdried

Sources & evidence

ORD record
ord-2e22ce89d7eb4ad78f301e3a0d6f4330
Source dataset
uspto-grants-2007_04
Patent number
US07202360B2

Reaction notes

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