反应详情

56 g of 1-acetyl-4-(2,4-difluorobenzoyl)piperidine obtained in step A) was added to 190 ml of 6N hydrochloric acid, and then, the resulting mixture was refluxed for 5 hours. The reaction mixture was concentrated under a reduced pressure, 200 ml of 2-propanol was added to the residue, and then the mixture was stirred. The resulting solid was filtered and dried to obtain 46.6 g of the title compound (yield: 85%).

1. temperaturethe resulting mixture was refluxed for 5 hours
2. concentrationThe reaction mixture was concentrated under a reduced pressure, 200 ml of 2-propanol
3. additionwas added to the residue
4. filtrationThe resulting solid was filtered
5. customdried