Imidazole → 1-Phenylpyrazole

HRID 1270697Notes

Reaction equation

HRID 1270697 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:8]1[CH:12]=[CH:11]N=C1.[C:13](#[N:15])C>>[C:2]1([N:8]2[CH:12]=[CH:11][CH:13]=[N:15]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 795ImidazoleHCID 6342AcetonitrileHCID 7961Bromobenzene

Product 1

HCID 707691-Phenylpyrazole

Procedure

Operating protocol A (82° C., 48 hours) was followed using 117 mg of Chxn-Py-Al (0.4 mmoles), 211 μl of bromobenzene (2 mmoles), 204 mg of imidazole (3 mmoles) and 1.2 ml of acetonitrile.

Workup

  1. customA (82° C., 48 hours)

Sources & evidence

ORD record
ord-fc48c0b25fa447c6ab1628cd8a372c6b
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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