Pyrazole → 4-(1H-Pyrazol-1-yl)aniline

HRID 1270699Notes

Reaction equation

HRID 1270699 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[CH:12][CH:11]=[N:10]1>C(#N)C>[NH2:6][C:5]1[CH:7]=[CH:8][C:2]([N:9]2[CH:13]=[CH:12][CH:11]=[N:10]2)=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 1048PyrazoleHCID 78074-Bromoaniline

Product 1

HCID 5942744-(1H-Pyrazol-1-yl)aniline

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

General procedure B (82° C., 42 hours) was followed using 117 mg of Chxn-Py-Al (0.4 mmoles), 516 mg of 4-bromoaniline (3 mmoles), 136 mg of pyrazole (2 mmoles) and 1.2 ml of acetonitrile.

Workup

  1. customGeneral procedure B (82° C., 42 hours)

Sources & evidence

ORD record
ord-b8778862b99247fd881210292f2676d3
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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