3,5-Dimethylphenol → 4-(3,5-Dimethylphenoxy)benzonitrile

HRID 1270705Notes

Reaction equation

HRID 1270705 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.IC1C=CC=CC=1.I[C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[C:22]([C:21]1[CH:24]=[CH:25][C:18]([O:9][C:4]2[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=2)=[CH:19][CH:20]=1)#[N:23]

Participants

4

Reactant 3

HCID 79483,5-Dimethylphenol2×HCID 11575IodobenzeneHCID 764674-Iodobenzonitrile

Product 1

HCID 102630094-(3,5-Dimethylphenoxy)benzonitrile

Procedure

Example 3.1 was repeated, replacing the phenol with 244 mg of 3,5-dimethylphenol (2 mmoles) and the iodobenzene with 595 mg of 4-iodobenzonitrile (2.6 mmoles), the latter being added at the same time as the 3,5-dimethylphenol.

Sources & evidence

ORD record
ord-db3f3eabfcc745e1bb9463af2232e0da
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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