Phthalic Anhydride → HCID 18451549, compound

HRID 1270720Notes

Reaction equation

HRID 1270720 reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:10]1(=O)[O:15][C:13](=[O:14])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]12>CN(C)C=O.C(OCC)C>[Cl:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[N:4]1[C:13](=[O:14])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]2[C:10]1=[O:15]

Participants

5

Reactant 2

HCID 6811Phthalic AnhydrideHCID 2829302-Chloro-4-iodoaniline

Product 1

HCID 18451549HCID 18451549, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Procedure

2-Chloro-4-iodoaniline (12.65 g) and phthalic anhydride (7.4 g) are dissolved in 30 mL of dimethylformamide. The solution is heated to reflux for 16 hours. The reaction mixture is diluted with diethyl ether and washed with brine to yield a precipitate which is filtered off and washed with water and diethyl ether to yield N-(2-chloro-4-iodophenyl)phthalimide as a white solid.

Workup

  1. temperatureThe solution is heated
  2. temperatureto reflux for 16 hours
  3. washwashed with brine
  4. customto yield a precipitate which
  5. filtrationis filtered off
  6. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-564cbf77fcc641a0a7b0bf8cbe0ac85b
Source dataset
uspto-grants-2007_04
Patent number
US07202364B2

Reaction notes

Loading…