HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 4-Bromo-2-chloro-3,5-difluoroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 4-Bromo-3,5-difluoroaniline | HCID 2736260 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-2-chloro-3,5-difluoroaniline | HCID 18451521 | — |
Reaction Steps
4-Bromo-3,5-difluoroaniline (10.5 g, 50.5 mmol) is dissolved in DMF (100 mL). NCS (28.6 g, 50.5 mmol) is added portionwise at room temperature. After 48 hours, the reaction is diluted with Et2O and washed with brine. The separated organic phase is dried (Na2SO4) and concentrated to give an oil. The residue is purified by column chromatography (EtOAc/hexanes) to give 4-bromo-2-chloro-3,5-difluoroaniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07202364B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-412f43e343fe4ce2a34aeef9f39f29dd |
| Source note | uspto-grants-2007_04 |