HCID 18451515, compound → 7-(Trifluoromethyl)naphthalen-2-amine

HRID 1270756Notes

Reaction equation

HRID 1270756 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([C:14]([F:17])([F:16])[F:15])=[CH:9][CH:10]=2)[CH:5]=1)([O-])=O>[Ni].CO>[F:15][C:14]([F:16])([F:17])[C:8]1[CH:7]=[C:6]2[C:11]([CH:12]=[CH:13][C:4]([NH2:1])=[CH:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 1

HCID 18451515HCID 18451515, compound

Product 1

HCID 184515397-(Trifluoromethyl)naphthalen-2-amine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 2-nitro-7-trifluoromethylnaphthalene (650 mg, 2.7 mmol) and Raney nickel (65 mg) in methanol (10 mL) is stirred under H2 (1 atm) for 1 hour. Filtration of the catalyst and evaporation of the solvent gives 7-trifluoromethyl-2-aminonaphthalene as a yellow solid.

Workup

  1. filtrationFiltration of the catalyst and evaporation of the solvent

Sources & evidence

ORD record
ord-86ee25afe0f3476884fb3ed2bca83084
Source dataset
uspto-grants-2007_04
Patent number
US07202364B2

Reaction notes

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