反应详情

5-Bromo-2-iodobenzoic acid (100 g, 0.306 mol) is dissolved in THF (350 mL) and cooled in an ice bath. Borane-THF complex (460 mL of 1 M in THF, 0.460 mol) is added dropwise. After addition is complete, the reaction is warmed to room temp and stirred for 14 hours. The mixture is transferred a large erlenmeyer flask (4 L), cooled in an ice bath and carefully quenched with water (250 mL). Evaporation of the THF by rotary evaporator gives a white suspension which is treated with additional water (1 L) and then filtered and dried in a vacuum dessicator over P2O5 to give 5-bromo-2-iodobenzyl alcohol.

1. temperaturecooled in an ice bath
2. additionAfter addition
3. temperaturecooled in an ice bath
4. customcarefully quenched with water (250 mL)
5. customEvaporation of the THF
6. customby rotary evaporator
7. customgives a white suspension which
8. filtrationfiltered
9. dry with materialdried in a vacuum dessicator over P2O5