反应详情

4-Trifluoromethoxyaniline (100 g, 0.58 mol), di-tert-butyl carbonate (127 g, 0.58 mol) and 1 N NaOH solution (250 mL) are dissolved in THF (200 mL) and stirred at room temperature for 12 hours. The reaction mixture is extracted with EtOAc (500 mL). The organic layer is washed with 1 N HCl (500 mL), brine (250 mL) and dried (MgSO4). The solvent is removed by rotary evaporator to give N-BOC-4-trifluoromethoxyaniline.

1. extractionThe reaction mixture is extracted with EtOAc (500 mL)
2. washThe organic layer is washed with 1 N HCl (500 mL), brine (250 mL)
3. dry with materialdried (MgSO4)
4. customThe solvent is removed by rotary evaporator