反应详情

温度

80 °C

The above benzoic acid (120 g, 0.37 mol) is suspended in 1,4-dioxane (200 mL), stirred and warmed to 80° C. until dissolved. The solution is allowed to cool to room temperature and hydrogen chloride is bubbled into the reaction mixture for 30 minutes. Stirring is continued for 2 hours, during which time a precipitate forms. The precipitate is collected and washed with ice-cold water (1000 mL) and Et2O (500 mL) to give 5-trifluoromethoxyanthranilic acid as a solid.

1. dissolutionuntil dissolved
2. temperatureto cool to room temperature
3. customhydrogen chloride is bubbled into the reaction mixture for 30 minutes
4. stirringStirring
5. customThe precipitate is collected
6. washwashed with ice-cold water (1000 mL) and Et2O (500 mL)