2-((tert-Butoxycarbonyl)amino)-5-(trifluoromethoxy)benzoic acid → 2-amino-5-(trifluoromethoxy)benzoic Acid

Participants

Reaction Conditions

Reaction Steps

The above benzoic acid (120 g, 0.37 mol) is suspended in 1,4-dioxane (200 mL), stirred and warmed to 80° C. until dissolved. The solution is allowed to cool to room temperature and hydrogen chloride is bubbled into the reaction mixture for 30 minutes. Stirring is continued for 2 hours, during which time a precipitate forms. The precipitate is collected and washed with ice-cold water (1000 mL) and Et2O (500 mL) to give 5-trifluoromethoxyanthranilic acid as a solid.

Provenance & Evidence